Discoverative AI for Neuroscience
Hosted at AIAS+ Chen Institute Symposium for AI Advancing Science and Society
AIAS+ 2026 Symposium · Workshop W02 · San Francisco

Discoverative AI
for Neuroscience

Toward AI systems that form hypotheses, design experiments, and refine their own understanding of neural systems.

Friday, November 6, 2026 San Francisco, CA Two workshop sessions
Organized by
About the workshop

A new phase in the dialogue between AI and the brain.

AI and neuroscience have long evolved in tandem — early AI drew inspiration from the brain, and modern AI has now reached a capability that can fundamentally reshape how neuroscience is done.

This workshop explores a phase in which AI moves beyond data analysis and modeling to become an active participant in scientific discovery. We take inspiration from the history of neuroscience — how transformative ideas about the brain were conceived, tested, and refined — and build toward a more ambitious question:

Can AI systems learn to generate and pursue scientific insight at superhuman scale?

We envision discoverative AI systems that do not merely process data, but continuously formulate hypotheses, design experiments, generate data, and iteratively refine their understanding of neural systems — shifting from stochastic, human-expert-limited hypothesis generation to expansive, automated exploration of the brain's complexity.

How this differs from brain-inspired AI

Where NeuroAI efforts (e.g. at CSHL and NIH) build next-generation AI inspired by the brain, this workshop emphasizes the reverse direction: leveraging modern AI to advance neuroscience itself — systems that generate hypotheses, design experiments, and participate in iterative scientific discovery.

Themes & topics

What we'll explore

The workshop explores methods and questions that move neuroscience from prediction and pattern-recognition toward mechanistic understanding.

01

Neural & behavioral data

AI methods for modeling and interpreting complex, high-dimensional neural and behavioral recordings.

02

Hypothesis generation

Scientific reasoning and automated hypothesis generation about how neural systems work.

03

Closed-loop experiments

AI-driven experimental design, active learning, and closed-loop neuroscience.

04

Causal & mechanistic

Causal inference and mechanistic models that move past correlation toward how the brain computes.

05

Foundation models

Multimodal and foundation models trained across diverse brain and behavior datasets.

06

Brain-inspired memory

Brain-inspired and memory-centric AI architectures.

07

Scientific agents

Agents that plan, reason, and act within iterative discovery workflows.

08

Benchmarks & eval

Datasets, simulation environments, and evaluation frameworks for discoverative systems.

Invited speakers

Voices from both fields

Invited speakers will each give a 30-minute talk followed by 5 minutes of Q&A.

Lu Chen

Lu Chen

Stanford University

Professor of Neurosurgery and of Psychiatry and Behavioral Sciences at Stanford. Her research examines the cellular and molecular mechanisms of synapse function and synaptic plasticity.

Dongjin Song

Dongjin Song

University of Connecticut

Associate Professor in UConn's School of Computing. His research focuses on AI and machine learning for time-series analysis, graph learning, and evolving real-world systems.

Dong Song

Dong Song

University of Southern California

Associate Professor of Neurological Surgery and Biomedical Engineering at USC and director of the Neural Modeling and Interface Laboratory. His research includes neural modeling, memory prostheses, and neural interface technologies.

NIH

NIH NeuroAI Initiative

NIH
Emerging funding directions and research priorities at the intersection of AI and brain science.
Closing panel

Where does discoverative AI go next?

Invited speakers and attendees will discuss open challenges, future directions, and opportunities for collaboration.

Moderator
Dong Song
USC
Moderator
Dongjin Song
UConn
Program

Tentative workshop schedule

Invited presentations, audience Q&A, and a closing panel bringing together AI and neuroscience communities.

Tentative program: Friday, November 6, 2026 (Day 2). Session times are confirmed; speaker order and the final program may change as additional speakers are confirmed. Room assignment to be announced.
10:10 AM
Welcome and workshop framingDong Song and Dongjin Song
Organizers
10:15 AM
Invited Speaker - To be announced30-minute talk + 5-minute Q&A
Invited talk
10:50 AM
Invited Speaker - Lu Chen30-minute talk + 5-minute Q&A
Invited talk
11:25 AM
Invited Speaker - Dongjin Song30-minute talk + 5-minute Q&A
Invited talk
12:00 PM
Transition to lunch
Break
2:00 PM
Invited Speaker - Dong Song30-minute talk + 5-minute Q&A
Invited talk
2:35 PM
Panel discussionOpen challenges, future directions, and collaboration - moderated by Dong Song and Dongjin Song
Panel
3:20 PM
Closing remarks and next steps
Organizers
Participation

Join the conversation

Join for an in-person discussion of discoverative AI for understanding the brain.

  • Who should attend. Researchers and practitioners working across AI, neuroscience, biomedical engineering, cognitive science, and related fields.
  • Program. Invited talks, audience Q&A, and a closing panel.
  • Registration. Register through the official AIAS+ 2026 portal. There is no separate workshop registration or paper submission process.
Organizing team

Organizers

Dong Song
Dong Song
University of Southern California
Lead · Contact

Associate Professor of Neurological Surgery and Biomedical Engineering at USC, working at the intersection of neuroscience, AI, and brain–machine interfaces. His research models neural dynamics underlying memory and develops closed-loop neural interface technologies for decoding and modulating brain activity in naturalistic settings, supported by initiatives such as DARPA and the NIH BRAIN Initiative.

Dongjin Song
Dongjin Song
University of Connecticut

Associate Professor in the School of Computing at UConn; previously a research staff member at NEC Labs America. PhD from UCSD (2016). His research spans machine learning, data science, and deep learning for time-series analysis. Recipient of the NSF CAREER Award (2024) and the Frontiers of Science Award in Computer Science (2024), and co-organizer of the AI4TS and MiLeTS workshop series.

Lu Chen
Lu Chen
Stanford University

Professor of Neuroscience in the Department of Neurosurgery at Stanford School of Medicine. An experimental neuroscientist studying molecular players in long-term synaptic plasticity and how synapse function underlies learning, perception, and neurological disorders. Her work has been recognized by the Beckman Young Investigator Award, the Packard Fellowship, the W.M. Keck Distinguished Young Scholars Award, and a MacArthur Fellowship.

Advisory committee

Advisory Committee

Domain experts supporting the workshop across machine learning, data mining, and neural engineering.

Dr. Wei Cheng
NEC Labs America
Dr. Derek Aguiar
University of Connecticut
Dr. Yaguang Li
Google Brain
Dr. Zhengping Che
Midea
Dr. Sungyong Seo
Google Cloud AI
Dr. Chen Luo
Amazon A9
Dr. Abhishek Mukherji
Accenture Inc.
Dr. Xingjian Shi
HKUST
Dr. Jiayu Zhou
Michigan State University
Dr. Jilin Hu
Aalborg University
Dr. Fernando Gama
Morgan Stanley
Dr. Wei Zhu
Amazon
Dr. An Wang
Case Western Reserve University
Registration

Join us in San Francisco

All participants register through the official AIAS+ 2026 portal.

https://www.aiasplus.org
Register at aiasplus.org

Workshop registration is handled entirely through the AIAS+ 2026 Symposium — there is no separate registration system for this workshop.